Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain
نویسندگان
چکیده
منابع مشابه
Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression
We used gene targeting techniques to produce mice lacking the invariant chain associated with major histocompatibility complex (MHC) class II molecules. Cells from these mice show a dramatic reduction in surface class II, resulting from both defective association of class II alpha and beta chains and markedly decreased post-Golgi transport. The few class II alpha/beta heterodimers reaching the ...
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We have studied the consequences of invariant chain (Ii) and DM expression on major histocompatibility complex (MHC) class II function. Ii has a number of discrete functions in the biology of class II, including competitive blocking of peptide binding in the endoplasmic reticulum and enhancing localization in the endocytic compartments. DM is thought to act primarily in endosomes to promote dis...
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From the "Departments of Cellular and Developmental Biology, and Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138; the *Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London W21PG, England; and the SLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethescl...
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ژورنال
عنوان ژورنال: Immunity
سال: 1995
ISSN: 1074-7613
DOI: 10.1016/1074-7613(95)90122-1